Dissociatives effect on benzo tolerance?
Anybody else have the expertise of dissociatives attenuating a dependence on benzos? I’ve been caught in a cycle for some time of taking dissos (2F, 3-HO-PCP, MXPr, MXiPr) after which having to take flualprazolam (0.25-0.5mg) at night time to sleep. I’ve been documenting my benzo use since September, however the cycle has been occurring for longer. Nevertheless, I’ve seen I haven’t developed any form of tolerance to the flap. I’ve additionally chilly turkeyed off of it no less than Three occasions with none actual withdrawals. Some slight rebound signs, however nothing close to as dangerous as I’ve skilled coming off of sedatives up to now. I learn a examine as soon as on diazepam dependence in mice or rats. 4 teams: A1 (administered diazepam 21 days straight) and B1 (administered diazepam for 21 complete days, however with Three day breaks each 7 days), then A2 (identical as A1, however coadministered ketamine at sure intervals) and B2 (identical idea), and each teams with the ketamine administered noticed vastly lowered withdrawal signs. If I discover it once more, I’ll put up it. I used to be simply curious if anybody had skilled something related. I wouldn’t count on to have a tough time coming off of a comparatively small dose of benzos, however I wouldn’t have anticipated to construct no tolerance in any respect after utilizing it each day for months and months in a row. Edit: https://pubmed.ncbi.nlm.nih.gov/9593834/ There’s a examine suggesting NMDA receptor antagonists have an effect on benzo dependence. It could be the one I used to be considering of, however I keep in mind ketamine getting used particularly. Edit 2: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC47038/ Meant to put up that one. Extra articles are at all times good. Nonetheless unsure that’s the one I learn, although.

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