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Hello , i am presently testing a-phip and mdphp , i discovered them actually fascinating with a choice for a-phip however i am unable to discover a research for his or her affinity with dopamine and serotonin transporter , i anticipate dopamine to be stronger with a-phip with in vitro expertise however unsure about that , i aloso actually beloved to attempt md-phip or 4cl-phip as a result of i anticipate them to be higher with serotonin what are you are trough about that ?
( additionally excuse me if i’ve a poor english , my present language is definitely french 😅)
ps i additionally discover this studdy about some affinity which i discover fascinating :
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392131/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392131/)
Results of MDPV and associated analogs on the uptake of [3H]neurotransmitters at DAT, NET, and SERT in rat mind synaptosomes
Take a look at drugDAT uptake inhibition IC50 (nM)NET uptake inhibition IC50 (nM)SERT uptake inhibition IC50 (nM)DAT/SERT ratioCocaine211±19292±34313±171.48Amphetaminea93±1767±163,418±31436.75Mephedronea762±79487±66422±260.55Methylonea1,323±1331,031±1621,017±590.77MDPV4.1±0.526±83,349±305816.82*S*-MDPV2.1±0.29.8±1.0n.d.–*R*-MDPV382±53726±150n.d.–3,4-Catechol-PV11±111±1>10,000>9004-OH-3-MeO-PV784±87407±43>10,000>12α-PVP12±114±1>10,000>833α-PBP63±692±13>10,000>159α-PPP197±10445±39>10,000>50
