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I do know there are numerous chemical brokers (ex. 9-Methyl-β-carboline) which might be theorized to primarily kick the mesolimbic dopamine system into excessive gear.(https://pubmed.ncbi.nlm.nih.gov/20374418/)
Do any chemical substances work this fashion for the mu-opioid receptors? The endogenous opioid system performs an integral position in temper, enjoyment, anxiousness regulation and hedonic tone, which is commonly wrongly attributed to completely dopaminergic perform.