MXE was great but we should move onto new things (a comparison of every disso billed as the "next MXE" + a long rant about what else we should look into)
Individuals speak about MXE within the forlorn phrases they’d focus on a former lover, or an immense fish that had simply eluded their grasp after hours of combating. And its no marvel! I used to be lucky to catch MXE on the tail finish of its existence, pretty early on in my psychonautic profession. It was the primary dissociative I had tried after the usual DXM/Ketamine. It was miraculous to me, {that a} chemical might make me really feel this fashion, {that a} single substance might achieve this a lot and go to this point. And this was with the 2015 china batches, not even the legendary pre-ban UK stuff that had pushed the drug’s recognition. Nonetheless, it shaded my later explorations into the world of dissociatives and I, like many, discovered myself chasing that very same expertise with different substances. However maybe this has been in folly- I imagine there may be much more that the world of dissociatives has to supply and we’re limiting ourselves in our dedication to this single compound. So what made [MXE](https://erowid.org/experiences/exp.php?ID=108601) so nice? Drawing from reminiscences 5 years in the past and the little bit of experiences I racked up earlier than it was gone without end, it was insightful, introspective, extraordinarily euphoric, vivid and visible with a deep and spectacular gap at larger doses, and a stunning sociable stimulation at decrease doses. It was firmly hallucinogenic, had a psychedelic edge that many dissociatives had been missing, and most of all it was versatile- a colourful and fabulous get together or membership drug, nice for dancing or hanging out, however with seemingly limitless depth when you needed to push your doses larger and meditate in its grand cathedral sans physique. Most of all, was a top quality many customers describe as “magic”- that sense of marvel you get if you take it, the push and the joys and a sensation that “sure”, that is proper, that is precisely the place you want to be. It virtually introduced me to tears. As a result of few different novel dissociatives had been accessible concurrently with MXE, I didn’t have a lot alternative to see the way it fared together with different dissos. Since its premature demise, the novel psychoactive substance market has tried many occasions to capitalize on its legendary status- quite a lot of medication which have been developed since then had been marketed by way of their similarity to MXE, oftentimes with nonsensical naming conventions in an try to attract that affiliation. Right here’s my temporary abstract and comparability of quite a lot of them One thing else that has stood out about MXE is its near-universal appeal- whereas not everybody beloved it, a big quantity of individuals did. Maybe it was this consistency that constructed such a robust repute for it. Opinions on many of those different compounds fluctuate wildly, some discovering sure ones boring or uncomfortable which others discover thrilling and even use as a drug of alternative. So take my opinions with a grain of salt right here and delve into others’ experiences. ​ -[MXM](https://erowid.org/experiences/exp.php?ID=107738) (Methoxmetamine, 3-MeO-2’-Oxo-PCM): This doesn’t actually matter, because it existed concurrently with MXE. It most likely didn’t catch on because it was overshadowed by its stronger and extensively accessible PCE homologue. It at all times had restricted availability and disappeared completely from the market across the identical time MXE did. Nonetheless, out of all of the compounds on this put up, this one most likely got here the closest to the actual deal by way of results. I admittedly had restricted expertise, and solely tried it in excessive doses, however the gap carried that very same rush, that very same sense of marvel and euphoria. It dosed higher- with desired results coming in at 70 mg. It solely labored sublingual or oral too, which can have drained a few of its enchantment. Nonetheless, beggars can’t be choosers, if this one had come onto the scene a 12 months later than it did maybe it might’ve caught on extra. I believe it’s definitely price revisiting. ​ -[MXP](https://erowid.org/experiences/exp.php?ID=110086) (Methoxphenidine, 2-MeO-Diphenidine): Additionally doesn’t depend, for quite a lot of reasons- it additionally existed similtaneously MXE, and it’s not even an arylcyclohexylamine. Nonetheless, its title has led to an excessive amount of confusion. I don’t even suppose it was meant as an MXE mimic, MXP simply appeared just like the pure method to abbreviate Methoxphenidine. It wasn’t the identical at all- solely dosed orally and really excessive, had a impartial buzzing sinking gap, purposeful to a level however oddly sedating too. A novel and enjoyable drug, however not something like MXE. Additionally had an odd tolerance buildup and gave every week lengthy cross tolerance to different dissociatives. ​ -[DCK](https://erowid.org/experiences/exp.php?ID=107832) (Deschloroketamine, 2’-Oxo-PCM): This primary popped up in the marketplace shortly after MXE’s demise. All of its naming conventions hassle me- first they tried to run with “DXE”, the one factor this molecule has in frequent with MXE is that they’re arylcyclohexylamines. I’m glad that title didn’t stick. Even the DCK title is deceptive, as ketamine is outlined by its presence of a chlorine and oxygen. O-PCM could be a fantastic title for this one, however I digress. This one was cognitively fairly just like MXE at gap doses- the outlet had the same rush, the same magic, the same diploma of visuals and depth. DCK nevertheless is considerably extra sedating, with a lazy draining sofa lock within the gap that persists as an irritating immobility after the results put on off, a sense of haven simply woken up, however lasting for hours. At decrease doses it’s extra like low doses of normal ketamine, as soon as once more missing lots of the stimulation and vibrancy of MXE. It turned an interesting drug in its personal proper finally, suffered a hiatus, however made a comeback lately. ​ There was a lull within the growth of MXE-like medication for just a few years, with numerous enjoyable variations into completely different arylcyclohexylamines that may assist set up a lexicon for which substitutions completed which effects- we had been blessed with mass market availability of compounds like 3-MeO-PCE, O-PCE, 3-HO-PCE, 3-HO-PCP, and 2F-DCK. Rumors abounded of “HXE”, a 3-HO-2’-Oxo-PCE, which makes good sense as a supposedly fascinating compound from a design standpoint, although it appears only a few have really been in a position to expertise it. Then in 2019, curiosity in chasing the “subsequent MXE” out of the blue ratcheted again up, with the thought to put the “MXE substitutions” (that being the mixed 3-MeO-2’-Oxo moieties) on different base compounds. The primary one, seen in late 2019, was MXPr. ​ -[MXPr](https://erowid.org/experiences/exp.php?ID=113789) (Methoxpropamine, 3-MeO-2’-Oxo-PCPr): This was the primary PCPr compound seen in the marketplace. Strapping the MXE substitutions to it appeared like a reasonably protected wager to delve into this new base construction, although different substitutions on PCPr are definitely lively in vitro. Being billed as the subsequent MXE, MXPr was discovered to be in the end disappointing to many. It has a brief period, a shallow headspace, and doses fairly excessive. Nonetheless, I discovered it to be remarkably visible in proportion to its different results. It had a boring comedown that left me feeling dazed and ineffective, not significantly thrilling. It actually shined together with different substances nevertheless, including additional dissociation and shade as long as the opposite compound had enough stimulant properties. It’s significantly miraculous when mixed with 3-MeO-PCE. ​ -[MXiPr](https://erowid.org/experiences/exp.php?ID=114917)(Methoxisopropamine, 3-MeO-2’-Oxo-PCPr): Like MXPr, this was the primary compound to hit the market based mostly on the PCiPr construction, one other one that provides a probably fascinating base for different compounds. Because the title implied, it has additionally been billed as “the subsequent MXE”, and has confirmed to be a novel and fascinating compound in its personal proper. At excessive doses, the outlet is pleasant, colourful, euphoric and exhilarating and fairly stimulating, and may I even say ‘magical’. The comedown is stimulating and psychedelic. It has a shorter period and better dose than MXE nevertheless, and at decrease doses it’s pretty uninteresting and missing in vitality. ​ -[DMXE](http://nervewing.blogspot.com/2020/11/dmxe.html) (Deoxymethoxetamine, 3-Me-2’-Oxo-PCE): One other foolish title. Name it Methyloxetamine if you actually need to, like MeXE idk, its good to stay to conventions. That apart, this has confirmed to be one of many extra thrilling compounds to come back out since 2019, I’m at the moment drafting a report. [EDIT: I finished the report! It’s linked right there] What MXiPr lacks in stimulating euphoria and rush, this drug has in spades. Decrease doses are enjoyable, dancey, lively, social and thrilling. Larger doses can will let you sink right into a gap although it stays pretty purposeful in any other case. The comedown is equally stimulating and psychedelic and nice. It lacks the load and vivid depth of MXE however is a thrill in its personal particular method. My solely gripes are the pretty excessive dosage, near that of MXPr and MXiPr, and the quick period, additionally just like aforementioned compounds. I’d say that is the closest to precise MXE of the compounds which have been developed since its demise. ​ I’ve not but had the chance to attempt both DMXE or MXiPr together with different medication. I’m a busy bug. ​ ​ So there our quest ought to finish, lots of the structural analogues to MXE have been exhausted and there are new horizons to look in the direction of so far as dissociative growth is anxious. Maybe we shouldn’t be chasing this excessive anymore, however in search of new and thrilling results on the planet of dissociatives- maybe one thing extra miraculous, extra magical and thrilling and probably even helpful and therapeutic is hiding on the market, ready to be found. There’s three instructions we will go- We now have now demonstrated that we will reliably predict how modifications on the nitrogen are lively, how numerous substitutions will stay lively, and the way numerous alterations of the fragrant ring stay lively. [I wrote a whole long thing about this,](http://nervewing.blogspot.com/2020/10/new-drugs-designing-novel.html) however I’ll summarize a few of what I believe is most related. In altering the amine- We all know that every part from a methyl by way of numerous butyl alterations are lively and fascinating, particularly due to the event of MXPr and MXiPr. Varied ring buildings are fascinating too- from PCPy to PCMo or maybe a PCTMo. Riskier makes an attempt could be made with the poorly studied alkoxyamines, (just about simply your primary carbon chain with an oxygen caught in there someplace). An allyl additionally stays lively. From right here, you possibly can strap on all types of the acquainted confirmed substitutions and modifications (eg. 3-Me, 3-MeO, 4-MeO, 3-HO, 3-F, 3-Cl, 2’-Oxo), to realize a plethora of attainable results. The probabilities are actually limitless and restricted by synthesis! The nearer it’s to a well-known construction (Say, 3-MeO-PCM, or 3-HO-PCPr), the extra predictable it’s that the compound will probably be lively, fascinating, and sufficiently potent. I personally would like to see 3-MeO-PCM, 3-MeO-PCiPr, 3-Cl-PCE and 3-Me-PCE to start out with, although extra thrilling and “on the market” variations could be pretty to see too. In enjoying round with substitutions- I rattled off among the tried and true options- 3-Me, 3-MeO, 4-MeO, 3-HO, 3-F, 3-Cl, 2’-Oxo, alone or together (amongst another extra obscure ones which will work), however maybe it’s time to attempt new substitutions, on a extra acquainted base, similar to PCP or PCE. You’ll be able to take that acquainted alkane chain and seemingly maintain increasing it, although you lose some efficiency because it will get greater. So this could be -Et, -Pr, iPr, -EtO, -PrO and iPrO substitutions. Different attainable choices are thioalkanes, (say an MeO group with a sulfur as a substitute of the oxygen), or halogens- F- and Cl- have been demonstrated to be lively, how would a Br or I behave? Probably the most exercise and efficiency is retained with substitutions on the 3- place of the fragrant ring. On the cyclohexane, any number of substitutions could assist or hurt- its not completely identified but. In the meantime, if the amine is a hoop construction, that may additionally see substitutions, which seem only on the carbon furthest from the nitrogen, within the case of PCP that may be the Four place. Lastly, you possibly can swap in numerous fragrant rings instead of the same old phenyl- a thiophene really will increase efficiency, Yielding the TCx household of compounds. Maybe a furan or a benzyl group would work too. [Here](https://1.bp.blogspot.com/-cSUVxp9fo3g/X3ZTHtDQ5RI/AAAAAAAAChY/KjWseJJ-Y98lUZSUwgqKjE5dYEoSpMXzgCLcBGAsYHQ/s839/alks.png) [are](https://1.bp.blogspot.com/-inxeowjckWE/X3ZTM5eBIGI/AAAAAAAAChc/Z_-h77o0RrwIUZMDERftZdwqZxgd_IsOgCLcBGAsYHQ/s977/PCE.png) [a](https://1.bp.blogspot.com/-xNfVhBin1Vs/X3ZTe018boI/AAAAAAAAChs/z4RiO2Y60cIbvgCfBZoLOl_FE5VPEt-JACLcBGAsYHQ/s594/S.png) [number](https://1.bp.blogspot.com/-VhtMaM_hs-k/X3ZTnZP-NZI/AAAAAAAAChw/VPSPpCUJmIUYd_t-8JUTr4SguDOkh_M-QCLcBGAsYHQ/s978/Tertiarypercent2Brings.png) [of](https://1.bp.blogspot.com/-IVsYiEbtGtY/X3ZTsPfSUKI/AAAAAAAACh4/svswcARLRoM_qLUojfvYZ5wNjb9QGeSNACLcBGAsYHQ/s1345/secondarypercent2Brings.png) [examples](https://1.bp.blogspot.com/–zAp9WSFqHs/X3ZT4sVFjFI/AAAAAAAACiI/UnqW-geeeiMVIWetBEgmhv2lsWJd2_9pACLcBGAsYHQ/s1068/benzyl.png) [of](https://1.bp.blogspot.com/-0pbLXxF7o3k/X3ZUJQSi2xI/AAAAAAAACic/YfEeOLFW-8w-ZP31qaFvtmHEBVMvgMF-ACLcBGAsYHQ/s1257/PCEC.png) [possible](https://1.bp.blogspot.com/-c2uFecUpMpY/X3ZTYK9tefI/AAAAAAAAChk/LZA93rvgk949yHdW80wzfjy7gmp5ZsciACLcBGAsYHQ/s637/O.png) fascinating compounds to probably examine. ​ The factor is, we actually don’t know what will probably be lively till we attempt, the chances are really limitless and so many dissociatives are distinctive and wonderful in their very own proper with out having to have their designed constrained by their similarity to the legendary MXE. Maybe it has gone to relaxation to go away us to provide you with one thing higher in spite of everything~

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