The Real Differences Between 1P-LSD and LSD-25
I am getting actual fed up with all these youngsters not figuring out the best way to use google saying that these are totally different medication. **First lets take a look at metabolites:** [In vitro metabolic fate of nine LSD-based new psychoactive substances and their analytical detectability in different urinary screening procedures.]( >General, N-dealkylation and hydroxylation, in addition to mixtures of those steps predominantly catalyzed by CYP1A2 and CYP3A4, had been discovered. For ALD-52, 1P-LSD, and 1B-LSD, deacylation to LSD was noticed. There does appear to be an absence of knowledge on the pharmacokinetics, nevertheless it’s clear it’s metabolised into LSD. **However how does it actually evaluate to LSD?** [Return of the lysergamides. Part I: Analytical and behavioral characterization of 1-propionyl-d-lysergic acid diethylamide (1P-LSD)]( >It was discovered that 1P-LSD produced a dose-dependent enhance in HTR counts, and that it had ~38% (ED50 = 349.6 nmol/kg) of the efficiency of LSD (ED50 = 132.eight nmol/kg). Moreover, the HTR was abolished when 1P-LSD administration adopted pre-treatment with the selective 5-HT2A receptor antagonist M100907 (0.1 mg/kg, SC), which confirms that the behavioral response is mediated by activation of the 5-HT2A receptor. These outcomes point out that 1P-LSD produces LSD-like results in mice, in line with its classification as a serotonergic hallucinogen. However, the extent to which 1P-LSD may present psychoactive results in people much like LSD stays to be investigated. This lack of efficiency is to be anticipated with a professional drug **Psychedelics are totally different each time** That is one thing I haven’t got a supply for, nevertheless I do not suppose it is wanted. If you happen to had been to take 3.5 grams of mushrooms immediately, then one yr from now, you once more take 3.5 grams, the journeys could be utterly distinct from each other. This largely has to do with how psychedelics work off of how your feeling in that second and the place you’re in life at the moment. In conclusion, google earlier than you ask, and cease suggesting that these two medication are so distinct from each other when the variations are minute.

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25 thoughts on “The Actual Variations Between 1P-LSD and LSD-25”
  1. Approved and pinned for a while cause I agree. I’ve been quite absent in the little details of this sub for a few months now but I definitely see a fuck load of posts about 1P VS 25, enough that maybe this is a good idea to pin it.

  2. Hell yes to the last point. I’ve had trips on the same chemical, from the same batch, at the same dose, and if I didn’t know better could absolutely be convinced I took a different drug.

  3. Thanks for posting this. I’m 45 and quite experienced with LSD-25 but have been out of touch for the most part with psychedelics except for a few occasions over the last ten or twelve years and was somewhat confused as to the metabolization of 1-P and was hesitant to experiment with it. I feel much more confident now that I’m not dealing with something completely novel. Thanks again and great papers by the way.

  4. Well they have different CAS numbers and all are therefore different drugs, with almost indistinguishable effects
    This is probably like psilocybin and psilocin. Psilocybin probably does not cross the BBB and requires its metabolism to psilocin for effect.

    But conversely I have taken 4-AcO-DMT and psilocin and they are very different while many people,
    My wife included thought they were identical.

    In some of these prodrug cases variance in an individuals metabolism could play a role in which drug is more abundantly expressed in the nervous system, as long as said prodrug is able to cross the BBB on its own.

  5. I’m still curious about the time it takes to metabolize into lsd. If I take the LSD it works fast and all hits at once, so to speak. If 1p wouldn’t it take time and happen gradually causing it to peak lower and also have the tolerance effect just like trying to redose with LSD? Seems fine for low dose, but how about heroic doses? I’m not experienced with it, and I’m truly wanting to know if this is a thing or not.

  6. The only difference i noticed was that the colors and closed eye visuals were less vivid and intense on 1P vs Regular LSD… not to say that i didnt enjoy my 1P trip, it was pretty crazy… but i did miss the bright rainbow colors

  7. It actually doesn’t mean those are the same shit. It means that after ingesting it is metabolised to LSD-25 which metabolites can be found in urine. Just it.
    It doesn’t mean it’s the same thing and you have even quoted this “Nevertheless, the extent to which 1P-LSD might show psychoactive effects in humans similar to LSD remains to be investigated.”.
    It says clearly that it produces similar effects and not that it’s the same.
    Your whole post is just LMAO.

  8. oh so this is what all the peoplel who think they are doing the lsd from back in the day are doing nowadays. shows up on a reagent test as lsd.

    once it is metablized it is in a different part of your body so they effects are different than pure lsd-25.

  9. Hey im new to really the community as a whole to my understanding its kinda like same destination different routes meaning the peaks are the same but ive read that the come ups are different

  10. I get the first part but your random stance on it can be different is kinda obvious no one says it’ll be the same every time I don’t think I’ve heard anyone ever say that, not many people even say the first part it’s quite clear already

  11. Absolutely true, until we get pharmacokinetic data its all just anecdotal.

    The thing is due to the enzymes we have, it is widely thought that it is deacetylated in vivo, turning it into psilocin, therefore it should be similar. I know people who are very experienced with both who say they are identical

    I, however am experienced but think 4acoDMT is completely different, more DMT like than mushrooms

    The theory is that maybe folks like us lack large amounts of the enzyme or the enzyme is shaped a little different and a noticeable amount of 4acodmt makes it to the brain.

    Very interesting and a for sure paper in a high tier journal if you do the study

  12. From what I’ve seen in class 1p metabolizes into LSD so they are 95% the same but because of the extra pieces to molecule it causes a harder come up but after that the chemicals are THR exact same but every trip will be diff based on mindset(set) and where u are hanging out at (setting)

  13. Ald is noce but it’s also metabolizes to LSD after THR liver but due to the difference in molecules between ald and 1p THR come up is way diff but THR trip is exactly the same chemical wise. Again your mindset(set) and where ur at(setting).

  14. >If you were to take 3.5 grams of mushrooms today, then one year from now, you again take 3.5 grams, the trips can be completely distinct from one another. This in large part has to do with how psychedelics work off of how your feeling in that moment and where you are in life at that time.

    Yessss!! Mind blown.

  15. I unsubbed from here because when I’ve posted studies like this in the past they get ignored and/or ridiculed. Shame to see not a lot has changed in here, still a bunch of kids!

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